The theme for ISSICON 2026 is “Spine and Spinal Cord Injury Horizons 2026: Global Innovation, Integration & Excellence”. The epidemiology of spinal cord injury is undergoing a significant transition worldwide, with a growing proportion of cases being attributed to non-traumatic causes. Degenerative, infective, neoplastic, vascular, inflammatory, and metabolic conditions increasingly contribute to spinal cord dysfunction, particularly in ageing populations. In parallel, rapid advances in neuromodulation, rehabilitation technologies, and translational research are reshaping care pathways in both traumatic and non-traumatic spinal cord injuries. This evolving scenario demands a stronger emphasis on timely diagnosis, evidence-based interventions, comprehensive rehabilitation, and long-term outcome optimization.